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61-Year-Old with Alzheimer’s Mutation Defies Cognitive Decline

2/12/2025

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Summary

Story summary

A remarkable 61-year-old man carrying a PSEN2 mutation, typically associated with early-onset Alzheimer’s, defies expectations by maintaining normal cognitive function for a decade. This rare case, the third of its kind, challenges our understanding of Alzheimer’s, suggesting that genetic factors may offer unexpected resilience against the disease's damaging effects.

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Story summary

A remarkable 61-year-old man carrying a PSEN2 mutation, typically associated with early-onset Alzheimer’s, defies expectations by maintaining normal cognitive function for a decade. This rare case, the third of its kind, challenges our understanding of Alzheimer’s, suggesting that genetic factors may offer unexpected resilience against the disease's damaging effects.