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Yale Innovates Gene-Editing Therapy for Angelman Syndrome

2/18/2025

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Summary

Story summary

Yale researchers, led by Dr. Yong-Hui Jiang and Dr. Jiangbing Zhou, are pioneering gene-editing therapies to combat Angelman syndrome, a rare genetic disorder affecting one in 15,000 people. Their innovative STEP platform targets the mutation on chromosome 15, offering hope for those with severe disabilities and paving the way for future treatments of neurogenetic disorders.

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Story summary

Yale researchers, led by Dr. Yong-Hui Jiang and Dr. Jiangbing Zhou, are pioneering gene-editing therapies to combat Angelman syndrome, a rare genetic disorder affecting one in 15,000 people. Their innovative STEP platform targets the mutation on chromosome 15, offering hope for those with severe disabilities and paving the way for future treatments of neurogenetic disorders.