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Genetic Variants May Reduce Pain in Opioid Patients

2/25/2025

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Summary

Story summary

A groundbreaking 2025 study in the Journal of Pain Research reveals that specific genetic variants could influence pain levels in patients battling opioid use disorder. Those on opioid agonist therapy with the COMT rs4680 Val/Val and OPRM1 rs1799971 G allele variants experienced reduced pain intensity, although the research was limited by a small sample size.

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Story summary

A groundbreaking 2025 study in the Journal of Pain Research reveals that specific genetic variants could influence pain levels in patients battling opioid use disorder. Those on opioid agonist therapy with the COMT rs4680 Val/Val and OPRM1 rs1799971 G allele variants experienced reduced pain intensity, although the research was limited by a small sample size.