Back to today’s briefing

Story perspectives

Breakthrough Study Reveals RNA Splicing's Role in Cancer Growth

3/17/2025

44 6

Summary

Story summary

In a groundbreaking study, researchers from The Jackson Laboratory and UConn Health unveiled how cancer cells manipulate RNA splicing via the TRA2? gene to fuel tumor growth. By creating antisense oligonucleotides (ASOs) that restore the gene's natural "poison exon," they significantly hindered tumor survival, paving the way for innovative targeted therapies against aggressive cancers.

1 of 1

Story summary

In a groundbreaking study, researchers from The Jackson Laboratory and UConn Health unveiled how cancer cells manipulate RNA splicing via the TRA2? gene to fuel tumor growth. By creating antisense oligonucleotides (ASOs) that restore the gene's natural "poison exon," they significantly hindered tumor survival, paving the way for innovative targeted therapies against aggressive cancers.