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Genetic Shift Raises Fuchs' Corneal Dystrophy Risk in Women

3/25/2025

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Summary

Story summary

A groundbreaking study from UCL Institute of Ophthalmology uncovers that a genetic change in the TCF4 gene heightens the risk of Fuchs’ endothelial corneal dystrophy (FECD). Analyzing 894 patients, researchers discovered that over 50 copies of the CTG18.1 sequence are notably prevalent among Europeans and South Asians, particularly affecting women.

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Story summary

A groundbreaking study from UCL Institute of Ophthalmology uncovers that a genetic change in the TCF4 gene heightens the risk of Fuchs’ endothelial corneal dystrophy (FECD). Analyzing 894 patients, researchers discovered that over 50 copies of the CTG18.1 sequence are notably prevalent among Europeans and South Asians, particularly affecting women.