Back to today’s briefing

Story perspectives

1 in 3,000 Carry Dangerous FLCN Variant, Study Reveals

4/12/2025

43 10

Summary

Story summary

A groundbreaking study in Thorax uncovers that 1 in 3,000 people may harbor a dangerous FLCN variant tied to pneumothorax and renal cancer, a startling increase from earlier estimates. This research underscores the critical need for genetic testing for Birt-Hogg-Dubé syndrome in patients with a history of these conditions, regardless of their family background.

1 of 1

Story summary

A groundbreaking study in Thorax uncovers that 1 in 3,000 people may harbor a dangerous FLCN variant tied to pneumothorax and renal cancer, a startling increase from earlier estimates. This research underscores the critical need for genetic testing for Birt-Hogg-Dubé syndrome in patients with a history of these conditions, regardless of their family background.