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UCLA Study Reveals Autism-Schizophrenia Link via Chromosome 22

4/12/2025

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Summary

Story summary

UCLA researchers have uncovered a striking link between chromosome 22q11.2 deletion syndrome and altered brain connectivity in children, shedding light on autism and schizophrenia. Before puberty, brain regions are hyperconnected, but this changes to under-connectivity later, tied to a loss of dendritic spines. Targeting the protein GSK3-beta could pave the way for new treatments.

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Story summary

UCLA researchers have uncovered a striking link between chromosome 22q11.2 deletion syndrome and altered brain connectivity in children, shedding light on autism and schizophrenia. Before puberty, brain regions are hyperconnected, but this changes to under-connectivity later, tied to a loss of dendritic spines. Targeting the protein GSK3-beta could pave the way for new treatments.