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AI Uncovers PHGDH Gene's Role in Alzheimer’s Disease

4/26/2025

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Summary

Story summary

A groundbreaking study from the University of California San Diego reveals that the PHGDH gene, once considered a mere biomarker, actually triggers spontaneous Alzheimer’s disease. Published in Cell on April 23, researchers harnessed AI to uncover how PHGDH disrupts gene regulation in brain cells, paving the way for potential new treatments.

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Story summary

A groundbreaking study from the University of California San Diego reveals that the PHGDH gene, once considered a mere biomarker, actually triggers spontaneous Alzheimer’s disease. Published in Cell on April 23, researchers harnessed AI to uncover how PHGDH disrupts gene regulation in brain cells, paving the way for potential new treatments.