Story perspectives
Opioids Hinder Placebo Effects in Depression Treatments
5/4/2025
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Story summary
- Chronic opioid use dampens the brain's response to placebo antidepressants, according to a study in the Journal of Affective Disorders. While opioid users experienced diminished improvement with placebo treatments, ketamine's effectiveness remained unchanged. This highlights opioids' potential to interfere with natural mood regulation, complicating depression treatment outcomes.
