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CDC Updates HIV PEP Guidelines with New Regimens

5/8/2025

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Summary

Story summary

The CDC has revamped its HIV post-exposure prophylaxis (PEP) guidelines, introducing two effective once-daily regimens: Biktarvy and a combination of dolutegravir with tenofovir and emtricitabine. To maximize effectiveness, PEP must begin within 72 hours of exposure, with doxycycline as an additional option for select individuals.

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Story summary

The CDC has revamped its HIV post-exposure prophylaxis (PEP) guidelines, introducing two effective once-daily regimens: Biktarvy and a combination of dolutegravir with tenofovir and emtricitabine. To maximize effectiveness, PEP must begin within 72 hours of exposure, with doxycycline as an additional option for select individuals.