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Study Reveals Human DNase1 Production Lags Behind Murine

5/28/2025

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Summary

Story summary

In a recent study, researchers found that human DNase1 (hDNASE1) produced in P. pastoris was 70-80 times less than its murine counterpart (mDNase1). This disparity stems from difficulties in folding and post-translational processing. Despite attempts to optimize production, hDNASE1's yield remains a significant hurdle in matching mammalian system outputs.

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Story summary

In a recent study, researchers found that human DNase1 (hDNASE1) produced in P. pastoris was 70-80 times less than its murine counterpart (mDNase1). This disparity stems from difficulties in folding and post-translational processing. Despite attempts to optimize production, hDNASE1's yield remains a significant hurdle in matching mammalian system outputs.