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Western Diet Causes Lasting Vessel Damage in Mice

6/14/2025

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Summary

Story summary

Mice fed a Western diet for 48 weeks developed serious vessel abnormalities and became desensitized to VEGF-A, hindering insulin release, according to researchers at Karolinska Institutet. Although switching to a healthier diet improved some metabolic issues, lasting structural damage remained due to a "metabolic memory" tied to overactive aPKC in their endothelial cells.

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Story summary

Mice fed a Western diet for 48 weeks developed serious vessel abnormalities and became desensitized to VEGF-A, hindering insulin release, according to researchers at Karolinska Institutet. Although switching to a healthier diet improved some metabolic issues, lasting structural damage remained due to a "metabolic memory" tied to overactive aPKC in their endothelial cells.