Back to today’s briefing

Story perspectives

Neanderthal Gene Cuts Athletic Potential by 50%

8/13/2025

49 8

Summary

Story summary

A groundbreaking study by Dr. Dominik Macak uncovers that the Neanderthal AMPD1 variant significantly hampers enzyme activity—by 25% in lab proteins and a staggering 80% in engineered mice muscles. Found in 2-8% of Europeans, this ancient genetic trait slashes the chances of achieving elite athletic performance by half, bridging the gap between our past and present physiology.

1 of 1

Story summary

A groundbreaking study by Dr. Dominik Macak uncovers that the Neanderthal AMPD1 variant significantly hampers enzyme activity—by 25% in lab proteins and a staggering 80% in engineered mice muscles. Found in 2-8% of Europeans, this ancient genetic trait slashes the chances of achieving elite athletic performance by half, bridging the gap between our past and present physiology.