Story perspectives

New Drug Boosts Self-Control, Reduces Alcohol Cravings

8/15/2025

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Summary

Story summary

Researchers in Philadelphia found that tolcapone increases prefrontal cortex activity, enhancing self-control and lowering alcohol consumption in individuals with alcohol use disorder (AUD).
The study included 64 participants and indicates that medications enhancing prefrontal dopamine could provide new treatment options for AUD.
Senior author Joseph P. Schacht highlights the necessity for innovative pharmacological approaches to address impaired inhibitory control in AUD.

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Story summary

Researchers in Philadelphia found that tolcapone increases prefrontal cortex activity, enhancing self-control and lowering alcohol consumption in individuals with alcohol use disorder (AUD).
The study included 64 participants and indicates that medications enhancing prefrontal dopamine could provide new treatment options for AUD.
Senior author Joseph P. Schacht highlights the necessity for innovative pharmacological approaches to address impaired inhibitory control in AUD.