Story perspectives

Revolutionary Cancer Therapy Uses Engineered Bacteria to Target Tumors

8/16/2025

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Summary

Story summary

Columbia Engineering researchers created CAPPSID, a cancer therapy using engineered bacteria and an oncolytic virus to target tumors.
The therapy employs Salmonella typhimurium to deliver the virus directly into cancer cells, reducing off-target effects.
Initial mouse tests demonstrated effective tumor clearance, with plans for broader clinical applications.
A patent has been filed, and future research will focus on improving safety and efficacy for various cancers.

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Story summary

Columbia Engineering researchers created CAPPSID, a cancer therapy using engineered bacteria and an oncolytic virus to target tumors.
The therapy employs Salmonella typhimurium to deliver the virus directly into cancer cells, reducing off-target effects.
Initial mouse tests demonstrated effective tumor clearance, with plans for broader clinical applications.
A patent has been filed, and future research will focus on improving safety and efficacy for various cancers.