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Esketamine Nasal Spray Offers Rapid Relief for Depression

8/17/2025

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Summary

Story summary

Esketamine nasal spray shows rapid relief for treatment-resistant depression, with symptom improvement within 24 hours.
In a study of 378 participants, esketamine significantly reduced depressive symptoms compared to placebo over four weeks.
Side effects were mostly mild and temporary, with no reported deaths.
Findings support esketamine as a potential standalone treatment, pending further research on long-term effects.

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Story summary

Esketamine nasal spray shows rapid relief for treatment-resistant depression, with symptom improvement within 24 hours.
In a study of 378 participants, esketamine significantly reduced depressive symptoms compared to placebo over four weeks.
Side effects were mostly mild and temporary, with no reported deaths.
Findings support esketamine as a potential standalone treatment, pending further research on long-term effects.