Story perspectives

Stress Disrupts Decision-Making in Humans and Rodents

8/18/2025

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Summary

Story summary

Researchers from IIT Delhi and AIIMS studied decision-making in humans and rodents using the Iowa Gambling Task, revealing stress negatively impacts choices for both.
Lead author Dr. Varsha Singh highlights the necessity for better animal models for human neurological disorders.
Impairments in brain regions like the vmPFC affect decision-making differently across sex and age, aiming to connect animal studies with human health despite sample diversity limitations.

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Story summary

Researchers from IIT Delhi and AIIMS studied decision-making in humans and rodents using the Iowa Gambling Task, revealing stress negatively impacts choices for both.
Lead author Dr. Varsha Singh highlights the necessity for better animal models for human neurological disorders.
Impairments in brain regions like the vmPFC affect decision-making differently across sex and age, aiming to connect animal studies with human health despite sample diversity limitations.