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Declining Smell Linked to Early Alzheimer's Diagnosis

8/19/2025

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Summary

Story summary

A study in "Nature Communications" links a declining sense of smell to early Alzheimer's disease in mice and humans.
Researchers identified that microglia disrupt connections affecting smell processing.
Early diagnosis may enable timely treatment with amyloid-beta antibodies, potentially improving outcomes.
The findings are backed by brain samples and PET scans from Alzheimer's patients.

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Story summary

A study in "Nature Communications" links a declining sense of smell to early Alzheimer's disease in mice and humans.
Researchers identified that microglia disrupt connections affecting smell processing.
Early diagnosis may enable timely treatment with amyloid-beta antibodies, potentially improving outcomes.
The findings are backed by brain samples and PET scans from Alzheimer's patients.