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Nicotine May Slow Aging in Mice, Study Finds

8/22/2025

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Summary

Story summary

A study from the Shenzhen Institutes of Advanced Technology indicates lifelong oral nicotine may slow motor decline in aging mice.
Nicotine enhances energy balance and maintains gut microbial diversity, resulting in a biologically younger phenotype.
Researchers identified a gut-sphingolipid-energy axis through behavioral tracking and metabolomics.
Long-term safety of nicotine is uncertain, necessitating research into non-addictive alternatives.
Findings may inform the creation of cholinergic modulators for healthier aging.

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Story summary

A study from the Shenzhen Institutes of Advanced Technology indicates lifelong oral nicotine may slow motor decline in aging mice.
Nicotine enhances energy balance and maintains gut microbial diversity, resulting in a biologically younger phenotype.
Researchers identified a gut-sphingolipid-energy axis through behavioral tracking and metabolomics.
Long-term safety of nicotine is uncertain, necessitating research into non-addictive alternatives.
Findings may inform the creation of cholinergic modulators for healthier aging.