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Study Links Retinal Changes to Early Dementia Risk

8/27/2025

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Summary

Story summary

JAX researchers have identified retinal cell changes associated with early dementia risk after nearly ten years of studies.
The retina, akin to brain tissue, provides valuable insights into neurological health.
Mice with the MTHFR677C>T mutation exhibited retinal problems by six months, suggesting impaired blood flow and cognitive decline.
The study was co-led by Alaina Reagan and Gareth Howell.

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Story summary

JAX researchers have identified retinal cell changes associated with early dementia risk after nearly ten years of studies.
The retina, akin to brain tissue, provides valuable insights into neurological health.
Mice with the MTHFR677C>T mutation exhibited retinal problems by six months, suggesting impaired blood flow and cognitive decline.
The study was co-led by Alaina Reagan and Gareth Howell.