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Story perspectives

Christina Applegate Opens Up About MS Impact on Daughter

8/28/2025

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Story summary
  • Christina Applegate shared the emotional effects of her multiple sclerosis on her daughter, Sadie, in her podcast.
  • Applegate's diagnosis in 2021 has deeply affected Sadie, who finds it difficult to witness her mother's pain.
  • Despite these challenges, Sadie demonstrates resilience by assisting Applegate with daily activities.
  • Applegate continues to be transparent about her health struggles, including a recent hospitalization for severe pain.
  • Sadie is also dealing with health issues, having been diagnosed with postural orthostatic tachycardia syndrome (POTS).