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Genetic Link Found in Women's PCOS and Testosterone

8/30/2025

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Story summary
  • Researchers from Mount Sinai and Duke University found DNA variants in the DENND1A gene that elevate testosterone in women with polycystic ovary syndrome (PCOS).
  • This study links genetic changes to hormonal imbalances in PCOS, which affects 10-15% of women of reproductive age worldwide.
  • The results may inform new therapies aimed at regulating genes to normalize testosterone levels and reduce symptoms.