Story perspectives
Declining Smell May Signal Early Alzheimer's Diagnosis
9/3/2025
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Story summary
- Research in *Nature Communications* indicates a declining sense of smell may signal early Alzheimer's disease.
- Immune cells, or microglia, disrupt nerve connections between the olfactory bulb and locus coeruleus.
- This discovery may enable early diagnosis and treatment with amyloid-beta antibodies prior to cognitive decline.
- Findings are derived from studies on mice and analysis of brain tissue from Alzheimer's patients.
