Story perspectives

Neanderthal DNA Variant Linked to Athletic Performance Drop

9/4/2025

31 3

Summary

Story summary

Modern humans possess approximately 2% Neanderthal DNA, impacting muscle energy management.
The Neanderthal AMPD1 enzyme variant exhibits 25% lower activity than the modern version.
Carriers of this variant face a 50% reduced likelihood of achieving elite athletic success.
While reduced AMPD1 activity is prevalent and usually asymptomatic, it may slightly elevate varicose vein risk.
The variant's persistence indicates relaxed selection pressures during human evolution.

1 of 1

Story summary

Modern humans possess approximately 2% Neanderthal DNA, impacting muscle energy management.
The Neanderthal AMPD1 enzyme variant exhibits 25% lower activity than the modern version.
Carriers of this variant face a 50% reduced likelihood of achieving elite athletic success.
While reduced AMPD1 activity is prevalent and usually asymptomatic, it may slightly elevate varicose vein risk.
The variant's persistence indicates relaxed selection pressures during human evolution.