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Story summary
- The Seattle Seahawks will face the San Francisco 49ers on September 7, 2025, at Lumen Field.
- The 49ers are favored by 2.5 points, with predicted scores ranging from Seahawks 24-23 to 49ers 24-20.
- An estimated 53% of the crowd will be 49ers fans, impacting Seattle's home-field advantage.
- Last season, both teams won one game against each other in their matchups.
- The Seahawks will wear their college navy jerseys, last used in a season opener in 2013.
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