Story perspectives

Loss of Smell: Early Warning for Alzheimer's Disease?

9/6/2025

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Summary

Story summary

A study connects a diminished sense of smell to early Alzheimer's disease, indicating it may be a warning sign.
Researchers identified that microglia damage connections between the olfactory bulb and locus coeruleus, impairing smell.
Experts, including Dr. Amit Sachdev, emphasize that smell loss is often overlooked in Alzheimer's diagnoses.
The study utilized brain samples, PET scans, and mouse studies to support these findings.
Further research is required to assess if smell changes can predict disease progression.

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Story summary

A study connects a diminished sense of smell to early Alzheimer's disease, indicating it may be a warning sign.
Researchers identified that microglia damage connections between the olfactory bulb and locus coeruleus, impairing smell.
Experts, including Dr. Amit Sachdev, emphasize that smell loss is often overlooked in Alzheimer's diagnoses.
The study utilized brain samples, PET scans, and mouse studies to support these findings.
Further research is required to assess if smell changes can predict disease progression.