Story perspectives

Study Links Waning JEV Immunity to Severe Dengue Risk

9/6/2025

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Summary

Story summary

Researchers from Duke-NUS Medical School and Nepal examined the relationship between Japanese encephalitis virus (JEV) immunity and severe dengue.
The five-year study involved over 500 patients in Nepal and was published in Science Translational Medicine.
Waning JEV immunity raises the risk of severe dengue symptoms.
Weak antibodies can enhance dengue virus entry into immune cells, worsening the disease.
Elevated chymase levels in patients with low JEV antibodies correlated with more severe dengue symptoms.

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Story summary

Researchers from Duke-NUS Medical School and Nepal examined the relationship between Japanese encephalitis virus (JEV) immunity and severe dengue.
The five-year study involved over 500 patients in Nepal and was published in Science Translational Medicine.
Waning JEV immunity raises the risk of severe dengue symptoms.
Weak antibodies can enhance dengue virus entry into immune cells, worsening the disease.
Elevated chymase levels in patients with low JEV antibodies correlated with more severe dengue symptoms.