Ole Miss Rebels vs. Kentucky Wildcats: SEC Showdown Preview

The No. 20 Ole Miss Rebels will face the Kentucky Wildcats in a pivotal SEC matchup on Saturday, September 6, 2025, at Kroger Field in Lexington, Kentucky. Both teams enter the game with 1-0 records, with Ole Miss coming off a dominant 63-7 victory over Georgia State, while Kentucky narrowly defeated Toledo 24-16. Kickoff is scheduled for 3:30 p.m. ET, and the game will be broadcast on ABC.

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Ole Miss will start redshirt-sophomore quarterback Austin Simmons, who had a strong debut, throwing for 341 yards and three touchdowns against Georgia State, despite two interceptions. The Rebels' running back Kewan Lacy also made an impact, rushing for 108 yards and three touchdowns. Kentucky's offense, led by quarterback Zach Calzada, struggled in their opener, completing only 10 passes for 85 yards. The Wildcats will rely heavily on their running game, featuring Dante Dowdell, who rushed for 129 yards against Toledo.

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This matchup carries significant historical weight, as Kentucky upset Ole Miss in Oxford last season, a loss that ultimately affected Ole Miss's playoff aspirations. The last four meetings between these teams have been closely contested, with each game decided by three points or fewer. Ole Miss has not lost in Lexington since 2010, but the Wildcats are eager to end their eight-game home losing streak against Power 4 teams.

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The current betting line favors Ole Miss by 9.5 to 10 points. Various predictive models, including Connelly’s SP+ and the College Football Power Index, give Ole Miss an 84% chance of victory, projecting a margin of around 16.1 points. National media predictions largely favor Ole Miss, with many experts expecting a comfortable win due to Kentucky's offensive struggles.

Kentucky vs Ole Miss predictions: Experts overwhelmingly back one side in revenge game

Lane Kiffin, head coach of Ole Miss, expressed the importance of this game, stating, “We spent a lot of time this offseason on Kentucky. That was a really hard loss to deal with, especially with the offensive struggles in the game.” Mark Stoops, Kentucky's head coach, emphasized the need for his team to focus on the present, saying, “The focus is on this week, this game.”

Kentucky vs. Ole Miss: Staff Predictions

Critics point to Kentucky's lackluster offensive performance in their opener as a significant concern. Analysts have noted that if Kentucky cannot improve their passing game, they may struggle to keep pace with Ole Miss's high-powered offense. Additionally, some experts believe that Ole Miss's defense, despite losing key players to the NFL, still possesses the talent to challenge Kentucky's offense effectively.

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Following this matchup, Ole Miss will look to build momentum as they continue their SEC schedule, while Kentucky aims to regain confidence and establish a winning streak. The outcome of this game could significantly impact both teams' trajectories for the remainder of the season.

What channel is Kentucky vs Ole Miss on today? Time and streaming info for week two

• “We’re gonna have to prepare really well, this is an extremely well-coached team.” — Lane Kiffin, Head Coach, Ole Miss

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This game promises to be a critical early-season test for both teams, with implications that could resonate throughout the SEC season.

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