Story perspectives
Dengue Infection Boosts Immunity for Future Infections
9/9/2025
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Story summary
- A Duke-NUS Medical School study shows dengue infection enhances immune responses to future infections and vaccines.
- Natural dengue infection reprograms innate immune cells, resulting in stronger antibody responses compared to vaccination.
- Blood samples from U.S. and Singapore participants revealed distinct gene activity in dengue-experienced individuals.
- Waning immunity from Japanese encephalitis vaccination correlates with increased dengue severity.
- Vaccinated individuals experience milder dengue cases, but this protection decreases over time.
