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Study Links Low Lithium Levels to Alzheimer's Risk

9/10/2025

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Summary

Story summary

Research shows lower lithium levels in the prefrontal cortex of individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD).
Dr. Bruce Yankner's study at Harvard found reduced lithium in brain samples from AD and MCI patients.
Lithium concentrated in amyloid plaques, indicating a potential role in AD pathology.
Low lithium diets in mouse models led to increased amyloid plaques and cognitive decline.
A clinical trial for lithium orotate aims to evaluate its safety and efficacy in humans.

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Story summary

Research shows lower lithium levels in the prefrontal cortex of individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD).
Dr. Bruce Yankner's study at Harvard found reduced lithium in brain samples from AD and MCI patients.
Lithium concentrated in amyloid plaques, indicating a potential role in AD pathology.
Low lithium diets in mouse models led to increased amyloid plaques and cognitive decline.
A clinical trial for lithium orotate aims to evaluate its safety and efficacy in humans.