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LSD Shows Promise in Treating Generalized Anxiety Disorder

9/11/2025

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Summary

Story summary

A JAMA study reveals that LSD significantly alleviates symptoms of generalized anxiety disorder (GAD).
Mind Medicine Inc. tested 198 adults across 22 sites with varying doses of MM120, a pharmaceutical-grade LSD.
The 100-microgram dose was most effective, with 65% of participants showing clinical response and 48% in remission after 12 weeks.
Current treatments are ineffective for about 50% of GAD patients, underscoring the need for alternatives.
The FDA has granted Breakthrough Therapy Designation to MM120, facilitating expedited approval, while Phase 3 trials continue to evaluate long-term effects and safety.

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Story summary

A JAMA study reveals that LSD significantly alleviates symptoms of generalized anxiety disorder (GAD).
Mind Medicine Inc. tested 198 adults across 22 sites with varying doses of MM120, a pharmaceutical-grade LSD.
The 100-microgram dose was most effective, with 65% of participants showing clinical response and 48% in remission after 12 weeks.
Current treatments are ineffective for about 50% of GAD patients, underscoring the need for alternatives.
The FDA has granted Breakthrough Therapy Designation to MM120, facilitating expedited approval, while Phase 3 trials continue to evaluate long-term effects and safety.