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Vitamin B3 Shows Promise in Treating Fatty Liver Disease

9/12/2025

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Summary

Story summary

Researchers found that miR-93 exacerbates metabolic-associated fatty liver disease (MASLD), affecting about 30% of the global population.
Professor Jang Hyun Choi's team identified miR-93 as a genetic regulator that increases lipid buildup and inflammation by inhibiting SIRT1.
Gene-editing in mice showed that blocking miR-93 reduced liver fat and improved metabolism.
Niacin (vitamin B3) effectively suppressed miR-93 and restored lipid metabolism, suggesting its potential as a treatment for MASLD.

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Story summary

Researchers found that miR-93 exacerbates metabolic-associated fatty liver disease (MASLD), affecting about 30% of the global population.
Professor Jang Hyun Choi's team identified miR-93 as a genetic regulator that increases lipid buildup and inflammation by inhibiting SIRT1.
Gene-editing in mice showed that blocking miR-93 reduced liver fat and improved metabolism.
Niacin (vitamin B3) effectively suppressed miR-93 and restored lipid metabolism, suggesting its potential as a treatment for MASLD.