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Story summary
- Researchers found that allyl alcohol converts to acrolein, causing an 'aldehyde storm' in the blood.
- This accumulation damages the liver, particularly in individuals with the ALDH2*2 gene variant.
- ALDH2 normally detoxifies harmful aldehydes, including acrolein, linked to health issues like cardiovascular disease.
- A study on knock-in mice revealed that ALDH2 dysfunction leads to acute liver injury.
- Depleted glutathione levels increase oxidative stress and ferroptosis, further harming the liver.
