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Key NFL Inactive Players Revealed Before Kickoff

9/21/2025

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Summary

Story summary

NFL teams will announce inactive players about 90 minutes before kickoff: 11:30 a.m. ET for early games and 2:30 p.m. ET for late games.
D'Andre Swift (CHI) may play; if not, Kyle Monangai could see more action.
Zach Charbonnet (SEA) is doubtful, likely giving Kenneth Walker III most RB touches.
Jaxon Smith-Njigba (SEA) is ill but may recover by kickoff.
Brock Purdy (SF) is inactive; Mac Jones starts with Adrian Martinez as backup. Jauan Jennings (SF) is expected to be inactive due to an ankle issue.

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Story summary

NFL teams will announce inactive players about 90 minutes before kickoff: 11:30 a.m. ET for early games and 2:30 p.m. ET for late games.
D'Andre Swift (CHI) may play; if not, Kyle Monangai could see more action.
Zach Charbonnet (SEA) is doubtful, likely giving Kenneth Walker III most RB touches.
Jaxon Smith-Njigba (SEA) is ill but may recover by kickoff.
Brock Purdy (SF) is inactive; Mac Jones starts with Adrian Martinez as backup. Jauan Jennings (SF) is expected to be inactive due to an ankle issue.