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James Conner Injured; Cardinals Face RB Uncertainty Ahead

9/22/2025

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Summary

Story summary

James Conner, running back for the Arizona Cardinals, suffered a right ankle injury and was carted off during the third quarter against the San Francisco 49ers.
The injury occurred after a 9-yard run, with players from both teams showing support.
Coach Jonathan Gannon confirmed the ankle injury but did not specify its severity.
Conner, 30, has a history of injuries, including a torn MCL.
If serious, Trey Benson may step in as the lead back.

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Story summary

James Conner, running back for the Arizona Cardinals, suffered a right ankle injury and was carted off during the third quarter against the San Francisco 49ers.
The injury occurred after a 9-yard run, with players from both teams showing support.
Coach Jonathan Gannon confirmed the ankle injury but did not specify its severity.
Conner, 30, has a history of injuries, including a torn MCL.
If serious, Trey Benson may step in as the lead back.