Story perspectives

New PET Tracer Revolutionizes Imaging for Cancer Diagnosis

9/23/2025

Summary

Story summary

Researchers developed a new positron emission tomography (PET) tracer, [64Cu]Cu-NOTA-EV-F(ab´)2, to image nectin-4 in triple-negative breast cancer (TNBC) and urothelial bladder carcinoma (UBC).
It enables same-day imaging, shortening diagnostic delays and guiding treatment decisions.
The fragmented antibody format yields higher tumor uptake and faster clearance than full-length antibodies.
The approach could expand to other cancers and targets, improving real-time monitoring.

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Story summary

Researchers developed a new positron emission tomography (PET) tracer, [64Cu]Cu-NOTA-EV-F(ab´)2, to image nectin-4 in triple-negative breast cancer (TNBC) and urothelial bladder carcinoma (UBC).
It enables same-day imaging, shortening diagnostic delays and guiding treatment decisions.
The fragmented antibody format yields higher tumor uptake and faster clearance than full-length antibodies.
The approach could expand to other cancers and targets, improving real-time monitoring.