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New Urine Test Could Revolutionize Prostate Cancer Detection

9/23/2025

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Summary

Story summary

Johns Hopkins University researchers developed a urine-based test for prostate cancer to reduce biopsies.
The test detects three biomarkers—TTC3, H4C5, and EPCAM—in urine from patients.
In 1,396 urine specimens, cancer patients showed higher biomarker levels than controls; levels fell after surgery.
The test may improve accuracy for prostate-specific antigen (PSA)-negative cases and aligns with rising incidence (3%/year, 2014–2019).

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Story summary

Johns Hopkins University researchers developed a urine-based test for prostate cancer to reduce biopsies.
The test detects three biomarkers—TTC3, H4C5, and EPCAM—in urine from patients.
In 1,396 urine specimens, cancer patients showed higher biomarker levels than controls; levels fell after surgery.
The test may improve accuracy for prostate-specific antigen (PSA)-negative cases and aligns with rising incidence (3%/year, 2014–2019).