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New Study Unveils Phosphatidylserine's Role in Immune Response

9/24/2025

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Summary

Story summary

Phosphatidylserine (PS) starts LC3-associated phagocytosis (LAP), a key immune process.
PS enrichment on phagosomal membranes recruits proteins to activate LAP.
LAP degrades dead cells and pathogens, shaping inflammation and anticancer responses.
The study appeared in Nature Cell Biology, from St. Jude Children’s Research Hospital.
Dr. Doug Green and Dr. Emilio Boada-Romero led, funded by the National Institutes of Health (NIH).

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Story summary

Phosphatidylserine (PS) starts LC3-associated phagocytosis (LAP), a key immune process.
PS enrichment on phagosomal membranes recruits proteins to activate LAP.
LAP degrades dead cells and pathogens, shaping inflammation and anticancer responses.
The study appeared in Nature Cell Biology, from St. Jude Children’s Research Hospital.
Dr. Doug Green and Dr. Emilio Boada-Romero led, funded by the National Institutes of Health (NIH).