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Story summary
- Crabp1 neurons, a subtype of hypothalamic neurons, regulate energy expenditure and respond to environmental cues.
- Activation of Crabp1 neurons increases activity and thermogenesis; silencing them leads to obesity.
- Obesity is a complex disease shaped by biology, environment, and stigma; media like The Biggest Loser amplified misperceptions.
- Findings suggest obesity treatments should target energy expenditure, not just calorie restriction.
