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Breakthrough Study Identifies Key Receptor for Tick-Borne Encephalitis

9/25/2025

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Summary

Story summary

Researchers from Albert Einstein College of Medicine and collaborating institutions identified LRP8 as a receptor for tick-borne encephalitis virus (TBEV), advancing infection understanding.
CRISPR-Cas9 showed LRP8 is required for TBEV entry.
A soluble LRP8 decoy receptor neutralized TBEV in vitro and protected mice from severe disease.
Findings could inform targeted therapies and vaccines for TBEV and related flaviviruses.

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Story summary

Researchers from Albert Einstein College of Medicine and collaborating institutions identified LRP8 as a receptor for tick-borne encephalitis virus (TBEV), advancing infection understanding.
CRISPR-Cas9 showed LRP8 is required for TBEV entry.
A soluble LRP8 decoy receptor neutralized TBEV in vitro and protected mice from severe disease.
Findings could inform targeted therapies and vaccines for TBEV and related flaviviruses.