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Drug-Resistant Infections Surge 460% in U.S. Since 2019

9/26/2025

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Summary

Story summary

The CDC reports a rise in U.S. drug-resistant infections, led by NDM-producing carbapenem-resistant Enterobacterales (NDM-CRE).
NDM-CRE infections surged 460% from 2019 to 2023, with 12,700 infections and 1,100 deaths in 2020.
Infection rates rose 70% in the period, with 4,341 cases in 2023.
Treatment options remain limited, with only two effective antibiotics; misuse and COVID pandemic use drive the rise.

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Story summary

The CDC reports a rise in U.S. drug-resistant infections, led by NDM-producing carbapenem-resistant Enterobacterales (NDM-CRE).
NDM-CRE infections surged 460% from 2019 to 2023, with 12,700 infections and 1,100 deaths in 2020.
Infection rates rose 70% in the period, with 4,341 cases in 2023.
Treatment options remain limited, with only two effective antibiotics; misuse and COVID pandemic use drive the rise.