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Study Reveals Early Inflammation Signals Rheumatoid Arthritis Onset

9/26/2025

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Summary

Story summary

A seven-year study from the University of Colorado Anschutz shows rheumatoid arthritis begins years before symptoms, with body-wide inflammation.
Published in Science Translational Medicine, the work maps immune changes in at-risk individuals, with pro-inflammatory B cells and T helper cells.
A separate study found hydroxychloroquine did not prevent RA in high-risk individuals, underscoring the need for biomarkers and prevention.

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Story summary

A seven-year study from the University of Colorado Anschutz shows rheumatoid arthritis begins years before symptoms, with body-wide inflammation.
Published in Science Translational Medicine, the work maps immune changes in at-risk individuals, with pro-inflammatory B cells and T helper cells.
A separate study found hydroxychloroquine did not prevent RA in high-risk individuals, underscoring the need for biomarkers and prevention.