Insights into the Longevity of Maria Branyas Morera

Maria Branyas Morera, who passed away in August 2024 at the age of 117, was recognized as the world's oldest verified living person. Born in the United States and later relocating to Catalonia, Spain, in 1915, she lived through significant historical events, including wars and pandemics, and even contracted Covid-19 at the age of 113. Before her death, Branyas requested that researchers study her DNA to uncover the secrets behind her extraordinary lifespan.

LADbible

Researchers from the University of Barcelona and the Josep Carreras Leukaemia Research Institute conducted a comprehensive analysis of Branyas's biological samples, including blood, saliva, urine, and stool. Their findings indicated that her biological age was estimated to be 10 to 15 years younger than her chronological age. Dr. Manel Esteller, the lead researcher, noted that while Branyas inherited favorable genetic traits, her lifestyle choices played a crucial role in her longevity. She maintained an active lifestyle, avoided smoking and drinking, and engaged socially, all of which contributed to her overall health.

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A significant focus of the study was Branyas's daily consumption of yoghurt, particularly the Spanish brand La Fageda, which she consumed up to three times a day. Researchers highlighted that this probiotic-rich food likely supported her gut health and immune system. Eloy Santos, a PhD student involved in the research, emphasized that the high levels of beneficial bacteria and fiber in her diet helped maintain a thriving gut microbiome, which is linked to lower inflammation levels and better overall health.

WalesOnline

The study's results, published in *Cell Reports Medicine*, suggest that extreme longevity is influenced by a combination of genetic and environmental factors. Branyas's case provides insights into the biological mechanisms of aging, indicating that advanced age does not necessarily correlate with poor health. The researchers aim to use these findings to explore potential biomarkers for healthy aging and strategies to enhance life expectancy.

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While the findings regarding Branyas's longevity are compelling, experts caution against drawing definitive conclusions from a single case study. Immaculata De Vivo, a molecular geneticist at Harvard University, noted the importance of larger, well-controlled population studies to validate these results. She emphasized that while genetics and lifestyle can influence health outcomes, disease causation is often probabilistic rather than absolute.

New York Times

Maria Branyas Morera's life and the subsequent research into her longevity highlight the complex interplay between genetics, lifestyle, and diet in achieving a long and healthy life. Her story serves as a reminder of the potential benefits of a balanced diet, active living, and social engagement, while also underscoring the need for further research to understand the mechanisms of aging.

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