Story perspectives

Leucovorin for Autism: Hope or Controversy?

9/28/2025

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Summary

Story summary

Dr. Richard Frye's research suggests leucovorin could help some children with autism, including improved communication.
The FDA has approved leucovorin for cerebral folate deficiency, but autism use remains controversial.
Critics, including scientists and health officials, urge larger trials before broader promotion, amid public trust concerns.
Some parents report improvements, while experts call for studies to determine dosing and candidate suitability.

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Story summary

Dr. Richard Frye's research suggests leucovorin could help some children with autism, including improved communication.
The FDA has approved leucovorin for cerebral folate deficiency, but autism use remains controversial.
Critics, including scientists and health officials, urge larger trials before broader promotion, amid public trust concerns.
Some parents report improvements, while experts call for studies to determine dosing and candidate suitability.