Story perspectives

Study Links Prenatal DEHP Exposure to Mouse DSD Risks

9/28/2025

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Summary

Story summary

Disorders of Sexual Development (DSD) in LhcgrW495X/+ mice arise with di(2-ethylhexyl) phthalate (DEHP) exposure; wild-type mice resilient.
Low-dose prenatal DEHP exposure triggers DSD in LhcgrW495X/+ mice; WT mice resist.
High-dose DEHP exposure resulted in more severe DSD in LhcgrW495X/+ mice.
Limitations: lack of cell experiments; narrow developmental scope.
Recommendations: minimize prenatal environmental endocrine disruptors (EEDs) exposure and monitor DSD-variant fetuses.

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Story summary

Disorders of Sexual Development (DSD) in LhcgrW495X/+ mice arise with di(2-ethylhexyl) phthalate (DEHP) exposure; wild-type mice resilient.
Low-dose prenatal DEHP exposure triggers DSD in LhcgrW495X/+ mice; WT mice resist.
High-dose DEHP exposure resulted in more severe DSD in LhcgrW495X/+ mice.
Limitations: lack of cell experiments; narrow developmental scope.
Recommendations: minimize prenatal environmental endocrine disruptors (EEDs) exposure and monitor DSD-variant fetuses.