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Blocking DGAT2 Enzyme Restores Brain Function, Targets Alzheimer's Risk

9/29/2025

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Summary

Story summary

Blocking the enzyme DGAT2 in mice restored microglia function and reduced toxic plaques.
Purdue University and Cleveland Clinic researchers found microglia accumulate fat, impairing clearance of toxic proteins.
Female mice showed greater brain-fat buildup, suggesting higher Alzheimer’s risk in women.
Findings could lead to repurposing existing drugs, highlighting metabolism’s role in brain aging.

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Story summary

Blocking the enzyme DGAT2 in mice restored microglia function and reduced toxic plaques.
Purdue University and Cleveland Clinic researchers found microglia accumulate fat, impairing clearance of toxic proteins.
Female mice showed greater brain-fat buildup, suggesting higher Alzheimer’s risk in women.
Findings could lead to repurposing existing drugs, highlighting metabolism’s role in brain aging.