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Study Reveals Nuclear Hypertrophy in Cancer Cells Is Temporary

9/30/2025

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Summary

Story summary

KAIST researchers report nuclear hypertrophy in cancer cells is a temporary response to replication stress, not a malignancy indicator.
The study links nuclear enlargement to DNA replication stress via actin protein aggregation.
In vivo, cancer cells with enlarged nuclei show reduced motility and metastatic potential.
The findings appeared in PNAS on September 9, 2025, led by Professor Joon Kim.

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Story summary

KAIST researchers report nuclear hypertrophy in cancer cells is a temporary response to replication stress, not a malignancy indicator.
The study links nuclear enlargement to DNA replication stress via actin protein aggregation.
In vivo, cancer cells with enlarged nuclei show reduced motility and metastatic potential.
The findings appeared in PNAS on September 9, 2025, led by Professor Joon Kim.