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New Score Predicts Invasive Breast Cancer Risk Effectively

10/1/2025

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Summary

Story summary

Researchers at King’s College London developed a polygenic risk score (PRS313) to predict invasive breast cancer risk in DCIS/LCIS.
In a cohort of 2,000 women, higher PRS313 scores linked to increased invasive cancer risk, especially for LCIS.
The study suggests combining PRS313 with traditional assessments to tailor treatment, but validation is needed due to LCIS's small sample.

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Story summary

Researchers at King’s College London developed a polygenic risk score (PRS313) to predict invasive breast cancer risk in DCIS/LCIS.
In a cohort of 2,000 women, higher PRS313 scores linked to increased invasive cancer risk, especially for LCIS.
The study suggests combining PRS313 with traditional assessments to tailor treatment, but validation is needed due to LCIS's small sample.