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UCSF Study Questions Vitamin B12's Role in Brain Health

10/1/2025

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Summary

Story summary

University of California, San Francisco (UCSF) study finds vitamin B12 levels may not protect aging brains, linking lower active B12 to cognitive decline and white matter damage on MRI.
In participants aged 71, processing speeds slowed and white matter damage occurred despite B12 above the U.S. minimum.
Researchers call revising current B12 guidelines to include functional biomarkers for earlier intervention.

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Story summary

University of California, San Francisco (UCSF) study finds vitamin B12 levels may not protect aging brains, linking lower active B12 to cognitive decline and white matter damage on MRI.
In participants aged 71, processing speeds slowed and white matter damage occurred despite B12 above the U.S. minimum.
Researchers call revising current B12 guidelines to include functional biomarkers for earlier intervention.