Story perspectives
Study Reveals Circular RNA's Role in Cancer Cell Growth
10/1/2025
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Story summary
- A study finds circular RNA circMAN1A2(2,3,4,5) binds CENPB mRNA, affecting cancer cell growth.
- The binding increases CENPB mRNA stability, altering mitotic fidelity and progression.
- Manipulating circMAN1A2 levels changes proliferation in several cancer cell lines, signaling therapeutic potential.
- The findings highlight circRNAs in gene regulation and point to new cancer treatments.
